Folic acid is considered a significant component for the early formation of the fetal nervous system. Lack of folic acid may increase the risk of open neural tube defects such as spina bifida and anencephaly. Because spina bifida and related defects develop 2-3 weeks after conception, al women of childbearing age should consume sufficient folic acid through supplementation (equivalent to 400 mcg). During pregnancy it is recommended that one consume 800-1000 mcg daily.