Are patients with infertility more likely to have pregnancy complications?

Patients with a history of infertility (i.e. experience a difficult time conceiving) who choose to conceive with assisted reproductive technologies (ART) do traditionally experience an increased number of complications during pregnancy. Common complications include preterm delivery, fetal growth failure, and fetal losses and increased rates of fetal loss and neonatal death. These are primarily related to placental failure due to poor placental vascular development. Almost all of these patients suffer from genetic and/or acquired thrombophilia, which is known to cause all of these complications as well as several others.