Preterm labor may be the result of an intrauterine infection, non-infectious intrauterine inflammation, placental ischemia (reduced placental blood flow), placental abruption, and placental thrombosis. In addition, preterm labor may often occur for reasons that we cannot identify (a.k.a. idiopathic). At KOFINAS PERINATAL we have successfully treated thousands of patients with tendencies for preterm labor. From our experience, most patients encounter preterm labor due to some degree of non-infectious inflammation. The use of the anti-inflammatory agent Indomethacin has been instrumental in the successful treatment of such patients.